Release from polymeric prodrugs: Linkages and their degradation

被引：116

作者：

D'Souza, AJM ^{[1
]}

Topp, EM ^{[1
]}

机构：

[1] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66047 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2004年 / 93卷 / 08期

关键词：

polymeric prodrugs; polymer-drug conjugate; passive drug targeting; controlled release; hydrolysis; intramolecular reaction;

D O I：

10.1002/jps.20096

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Polymeric prodrugs have evolved into a very useful class of drug delivery agents. Numerous polymeric prodrugs have been prepared for applications ranging from passive drug targeting to controlled release. The mechanistic aspects of the release processes, however, have not been clearly delineated. This review highlights the salient features of the chemical reactions that are responsible for drug release from these systems. The mechanisms of release from polymeric prodrugs employing various chemical linkages, esters, carbonates, carbamates, C=N linkage and amides, are discussed. (C) 2004Wiley-Liss, Inc.

引用

页码：1962 / 1979

页数：18

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