Role of CD83 in the immunomodulation of dendritic cells

被引:72
作者
Lechmann, M [1 ]
Zinser, E [1 ]
Golka, A [1 ]
Steinkasserer, A [1 ]
机构
[1] Univ Erlangen Nurnberg, Dept Dermatol, D-91052 Erlangen, Germany
关键词
dendritic cells; CD83;
D O I
10.1159/000065883
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Glycoprotein CD83 is one of the best-known maturation markers for human dendritic cells (DCs). The fact that CD83 is strongly upregulated together with co-stimulatory molecules such as CD80 and CD86 during DC maturation suggests it plays an important role in the induction of immune responses. Infection studies with herpes simplex virus type 1 (HSV-1) and the inhibition of the CD83 mRNA specific transport from the nucleus to the cytoplasm suggested a possible functional role for CD83. The first clear proof that CD83 is indeed important for DC biology came from recently performed studies using a soluble form of the extracellular CD83 domain. DC-mediated T cell proliferation could be completely inhibited using this recombinant molecule. Additional studies elucidated immunostimulatory as well as regulatory effects of the CD83 molecule. Furthermore, CD83-/- knockout mice revealed a block in CD4+ T cell generation, a new possible immunomodulatory function of CD83. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码:113 / 118
页数:6
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