Glycoprotein CD83 is one of the best-known maturation markers for human dendritic cells (DCs). The fact that CD83 is strongly upregulated together with co-stimulatory molecules such as CD80 and CD86 during DC maturation suggests it plays an important role in the induction of immune responses. Infection studies with herpes simplex virus type 1 (HSV-1) and the inhibition of the CD83 mRNA specific transport from the nucleus to the cytoplasm suggested a possible functional role for CD83. The first clear proof that CD83 is indeed important for DC biology came from recently performed studies using a soluble form of the extracellular CD83 domain. DC-mediated T cell proliferation could be completely inhibited using this recombinant molecule. Additional studies elucidated immunostimulatory as well as regulatory effects of the CD83 molecule. Furthermore, CD83-/- knockout mice revealed a block in CD4+ T cell generation, a new possible immunomodulatory function of CD83. Copyright (C) 2002 S. Karger AG, Basel.
机构:Antigen Presentation Research Group, Imperial College School of Medicine, Northwick Pk. Inst. for Med. Res., Harrow, Middlesex, HA1 3UJ, Watford Road
Knight, SC
Patterson, S
论文数: 0引用数: 0
h-index: 0
机构:Antigen Presentation Research Group, Imperial College School of Medicine, Northwick Pk. Inst. for Med. Res., Harrow, Middlesex, HA1 3UJ, Watford Road
机构:Antigen Presentation Research Group, Imperial College School of Medicine, Northwick Pk. Inst. for Med. Res., Harrow, Middlesex, HA1 3UJ, Watford Road
Knight, SC
Patterson, S
论文数: 0引用数: 0
h-index: 0
机构:Antigen Presentation Research Group, Imperial College School of Medicine, Northwick Pk. Inst. for Med. Res., Harrow, Middlesex, HA1 3UJ, Watford Road