Synthesis and antitumour activity of new dendritic polyamines-(imide-DNA-intercalator) conjugates:: potent Lck inhibitors

被引：30

作者：

Braña, MF

Domínguez, G

Sáez, B

Romerdahl, C

Robinson, S

Barlozzari, T

机构：

[1] Univ San Pablo, CEU, Fac Ciencias Expt & Tecn, Dept Quim Organ & Farmaceut, Madrid 28668, Spain

[2] BASF, Biores Corp, Worcester, MA 01605 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 37卷 / 07期

关键词：

antitumour; dendritic polyamines; intercalators; amides; Lck;

D O I：

10.1016/S0223-5234(02)01362-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of dendritic polyamines-(imide-DNA-intercalators) conjugates with different connectivity in their basic chain were synthesised and evaluated as antitumour compounds. Although their antiproliferative activity against HT-29 was not significant, conjugates 13 and 16 showed a promising profile as inhibitors of Lck. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：541 / 551

页数：11