Peripheral blood stem cell mobilization - A role for CXC chemokines

被引:54
作者
Pelus, LM [1 ]
Horowitz, D
Cooper, SC
King, AG
机构
[1] Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Walther Oncol Ctr, Walther Canc Inst, Indianapolis, IN 46202 USA
[3] Walther Canc Inst, Indianapolis, IN 46208 USA
[4] GlaxoSmithKline, Antimicrobial & Host Def Ctr Excellence Drug Disc, Dept Host Def, Collegeville, PA 19426 USA
关键词
hematopoietic stem cell mobilization; chemokines; GRO beta; transplantation;
D O I
10.1016/S1040-8428(01)00202-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Chemokines induce rapid hematopoietic stem and progenitor cell mobilization and synergize with hematopoietic cytokines in mobilizing stem and progenitor cells. These proteins alone and in combination offer new paradigms for autologous and allogeneic peripheral blood stem cell transplantation (PBSCT). The mechanisms responsible for hematopoietic stem cell (HSC) mobilization either with growth factors or chemokines are largely unknown, but a better understanding of these mechanisms will permit the development of novel, more rapid and efficacious regimens. Studies presented herein indicate that the CXCR2 chemokine receptor that interacts with selective chemokine ligands, particularly GRObeta/CXCL2 and GRObeta-T, may be the dominant receptor mediating hematopoietic cell mobilization, and that polymorphonuclear neutrophils may be the primary CXCR2 expressing target cell for stem and progenitor cell mobilization. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:257 / 275
页数:19
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