A highly stereospecific synthesis of (E)-α,β-unsaturated esters

被引：18

作者：

Barma, DK

Kundu, A

Bandyopadhyay, A

Kundu, A

Sangras, B

Briot, A

Mioskowski, C

Falck, JR

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

[3] Univ Louis Pasteur Strasbourg 1, Fac Pharm, Lab Synth Bioorgan, UMR 7514, F-67401 Illkirch Graffenstaden, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 30期

基金：

美国国家卫生研究院;

关键词：

chromium; olefination; stereoselective; condensations; halo esters;

D O I：

10.1016/j.tetlet.2004.05.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CrCl2-induced olefination of aldehydes using methyl dichloroacetate exclusively generates (E)-alpha,beta-unsaturated esters in excellent yields. The intermediate alpha-chloro-beta-hydroxy adducts could also be isolated in good yields under conditions of limited reagent. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5917 / 5920

页数：4

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