Immunology - The roots of antibody diversity

被引：20

作者：

Gearhart, PJ ^{[1
]}

机构：

[1] NIA, Lab Mol Gerontol, NIH, Baltimore, MD 21224 USA

来源：

NATURE | 2002年 / 419卷 / 6902期

关键词：

D O I：

10.1038/419029a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When faced with foreign molecules our antibodies mutate, allowing them to bind to the intruders more strongly. In a story full of surprises, it looks as though the mechanism of mutation has finally been revealed.

引用

页码：29 / +

页数：2

共 13 条

[11] Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein [J].

Phung, QH ;

Winter, DB ;

Cranston, A ;

Tarone, RE ;

Bohr, VA ;

Fishel, R ;

Gearhart, PJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (11) :1745-1751

[12] Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern [J].

Wiesendanger, M ;

Kneitz, B ;

Edelmann, W ;

Scharff, MD .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (03) :579-584

[13] DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes [J].

Zeng, XM ;

Winter, DB ;

Kasmer, C ;

Kraemer, KH ;

Lehmann, AR ;

Gearhart, PJ .

NATURE IMMUNOLOGY, 2001, 2 (06) :537-541

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