T helper cell-dependent, microbial superantigen-mediated B cell activation in vivo

被引：18

作者：

Tumang, JR ^{[1
]}

Zhou, JL ^{[1
]}

Gietl, D ^{[1
]}

Crow, MK ^{[1
]}

Elkon, KB ^{[1
]}

Friedman, SM ^{[1
]}

机构：

[1] HOSP SPECIAL SURG,DEPT MED,NEW YORK,NY 10021

来源：

AUTOIMMUNITY | 1996年 / 24卷 / 04期

关键词：

superantigens; autoimmunity; graft-versus-host disease; severe combined immunodeficient mice; systemic lupus erythematosus;

D O I：

10.3109/08916939608994717

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have utilized a severe combined immune-deficient (SCID) mouse adoptive transfer model to explore the in vivo immunostimulatory effects of bacterial superantigens (SAg). B cell reconstituted SCID recipients were treated with the Staphylococcus aureus-derived toxic shock syndrome toxin (TSST-1) alone or in conjunction with syngeneic L3T4(+) TSST-1-reactive T-h cells. Over several months of study, the repetitive administration of TSST-1 resulted in a prompt, transient increase in serum Ige levels, This response required both biologically active TSST-1 and T-h cells, These findings demonstrate that certain bacterial SAgs can promote T-h cell-dependent B cell activation and differentiation in vivo. These studies strengthen the analogy between SAg-mediated and allospecific T-h-B cell interactions responsible for the autoimmune sequelae of graft-versus-host disease.

引用

页码：247 / 255

页数：9