Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice

被引：33

作者：

Benedek, Gil ^{[1
,2
]}

Zhang, Jun ^{[1
,2
,5
]}

Nguyen, Ha ^{[1
,2
]}

Kent, Gail ^{[1
,2
]}

Seifert, Hilary ^{[1
,2
]}

Vandenbark, Arthur A. ^{[1
,2
,3
]}

Offner, Halina ^{[1
,2
,4
]}

机构：

[1] VA Portland Hlth Care Syst, Neuroimmunol Res, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[4] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 305卷

关键词：

Estrogen; EAE; Regulatory B cells; IL-10; M1/2; microglia; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; T-CELLS; ALTERNATIVE ACTIVATION; CNS REMYELINATION; DEFICIENT MICE; MICROGLIA; INFLAMMATION; PREGNANCY;

D O I：

10.1016/j.jneuroim.2016.12.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoregulatory sex hormones, including estrogen and estriol, may prevent relapses in multiple sclerosis during pregnancy. Our previous studies have demonstrated that regulatory B cells are crucial for estrogen-mediated protection against experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen dependent induction of alternatively activated (M2) macrophages/microglia that results in an increased frequency of regulatory B cells in the spinal cord of estrogen treated mice with EAE. We further demonstrate that cultured M2-polarized microglia promote the induction of regulatory B cells. Our study suggests that estrogen neuroprotection induces a regulatory feedback loop between M2 macrophages/microglia and regulatory B cells. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：59 / 67

页数：9

共 55 条

[1] Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool [J].