Nutrition and cancer prevention: A multidisciplinary perspective on human trials

被引：34

作者：

Forman, MR ^{[1
]}

Hursting, SD

Umar, A

Barrett, JC

机构：

[1] NCI, Ctr Canc Res, Basic Res Lab, Bethesda, MD 20892 USA

[2] NCI, Canc Res Ctr, Lab Biosyst & Canc, Rockville, MD 20852 USA

[3] NCI, Div Canc Prevent, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF NUTRITION | 2004年 / 24卷

关键词：

diet; carcinogenesis; molecular targets; epidemiology; carotenoids; retinoids;

D O I：

10.1146/annurev.nutr.24.012003.132315

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

More than one million Americans were expected to be diagnosed with cancer in 2003 (7a). Compelling experimental, epidemiological, and clinical evidence indicates that many cancers are preventable, especially because diet and nutrition are key factors in the modulation of cancer risk. The road to nutritional intervention in cancer prevention has led to successful trials as well as trials that did not reach their intended endpoints. This chapter reviews four case studies of trials, with two ending in success and two ending in null findings or adverse effects. The goal is to identify lessons learned from all four case studies and from the investigations of the complexities inherent to nutritional intervention trials. Additional insights are presented by the research addressing potential mechanisms underlying the endpoints of human trials. Future progress in nutrition and cancer prevention will require expertise from multidisciplinary teams to develop new knowledge about specific nutrients and dietary modifications within a framework of interaction between animal and human research.

引用

页码：223 / 254

页数：32

共 107 条

[21] Phase I trial of alpha-tocopherol effects on 13-cis-retinoic acid toxicity [J].

Dimery, IW ;

Hong, WK ;

Lee, JJ ;

GuilloryPerez, C ;

Pham, F ;

Fritsche, HA ;

Lippman, SM .

ANNALS OF ONCOLOGY, 1997, 8 (01) :85-89

[22] BIOAVAILABILITY OF BETA-CAROTENE IN HUMANS [J].

DIMITROV, NV ;

MEYER, C ;

ULLREY, DE ;

CHENOWETH, W ;

MICHELAKIS, A ;

MALONE, W ;

BOONE, C ;

FINK, G .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1988, 48 (02) :298-304

[23]

Earnest DL, 1999, AM J MED, V106, P43

[24]

Faivre J, 1997, EUR J CANCER PREV, V6, P132

[25] A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].

FEARON, ER ;

VOGELSTEIN, B .

CELL, 1990, 61 (05) :759-767

[26] Dietary fiber and the risk of colorectal cancer and adenoma in women [J].

Fuchs, CS ;

Giovannucci, EL ;

Colditz, GA ;

Hunter, DJ ;

Stampfer, MJ ;

Rosner, B ;

Speizer, FE ;

Willett, WC .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (03) :169-176

[27] INTESTINAL ABSORPTION AND METABOLISM OF VITAMIN A AND BETA-CAROTENE IN MAN [J].

GOODMAN, DWS ;

BLOMSTRAND, R ;

WERNER, B ;

HUANG, HS ;

SHIRATORI, T .

JOURNAL OF CLINICAL INVESTIGATION, 1966, 45 (10) :1615-+

[28] Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease [J].

Hennekens, CH ;

Buring, JE ;

Manson, JE ;

Stampfer, M ;

Rosner, B ;

Cook, NR ;

Belanger, C ;

LaMotte, F ;

Gaziano, JM ;

Ridker, PM ;

Willett, W ;

Peto, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (18) :1145-1149

[29] Growth and recurrence of colorectal polyps: A double-blind 3-year intervention with calcium and antioxidants [J].

Hofstad, B ;

Almendingen, K ;

Vatn, M ;

Andersen, SN ;

Owen, RW ;

Larsen, S ;

Osnes, M .

DIGESTION, 1998, 59 (02) :148-156

[30] The relationship between faecal bile acid profile with or without supplementation with calcium and antioxidants on recurrence and growth of colorectal polyps [J].

Hofstad, B ;

Vatn, MH ;

Andersen, SN ;

Owen, RW ;

Larsen, S ;

Osnes, M .

EUROPEAN JOURNAL OF CANCER PREVENTION, 1998, 7 (04) :287-294

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