Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes

被引：264

作者：

Fisher, MA

Plikaytis, BB

Shinnick, TM

机构：

[1] Ctr Dis Control & Prevent, Div AIDS STD & TB Lab Res, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

[2] Emory Univ, Program Microbiol & Mol Genet, Atlanta, GA 30322 USA

来源：

JOURNAL OF BACTERIOLOGY | 2002年 / 184卷 / 14期

关键词：

D O I：

10.1128/JB.184.14.4025-4032.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We used microarrays and real-time reverse transcription-PCR to analyze the global transcriptional response of Mycobacterium tuberculosis to low pH in vitro, which may mimic an environmental signal encountered by phagocytosed mycobacteria. Eighty-one genes were differentially expressed > 1.5-fold, including many involved in fatty acid metabolism. The most highly induced genes showed homology with nonribosomal peptide synthetases/polyketide synthases.

引用

页码：4025 / 4032

页数：8

共 54 条

[51] Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7 [J].