The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C-elegans

被引：129

作者：

Chin-Sang, ID ^{[1
]}

George, SE ^{[1
]}

Ding, M ^{[1
]}

Moseley, SL ^{[1
]}

Lynch, AS ^{[1
]}

Chisholm, AD ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Biol, Sinsheimer Labs, Santa Cruz, CA 95064 USA

来源：

CELL | 1999年 / 99卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(00)81675-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Eph receptor VAB-1 is required in neurons for epidermal morphogenesis during C. elegans embryogenesis. Two models were proposed for the nonautonomous role of VAB-1: neuronal VAB-1 might signal directly to epidermis, or VAB-1 signaling between neurons might be required for epidermal development. We show that the ephrin VAB-2 (also known as EFN-1) is a ligand for VAB-1 and can function in neurons to regulate epidermal morphogenesis. In the absence of VAB-1 signaling, ephrin-expressing neurons are disorganized. vab-2/efn-1 mutations synergize with vab-1 kinase alleles, suggesting that VAB-2/EFN-1 may partly function in a kinase-independent VAB-1 pathway. Our data indicate that ephrin signaling between neurons is required nonautonomously for epidermal morphogenesis in C. elegans.

引用

页码：781 / 790

页数：10

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