Effects of lithium and carbamazepine on thyroid hormone metabolism in rat brain

被引：36

作者：

Baumgartner, A ^{[1
]}

Pinna, G ^{[1
]}

Hiedra, L ^{[1
]}

Gaio, U ^{[1
]}

Hessenius, C ^{[1
]}

CamposBarros, A ^{[1
]}

Eravci, M ^{[1
]}

Prengel, H ^{[1
]}

Thoma, R ^{[1
]}

Meinhold, H ^{[1
]}

机构：

[1] FORMULA BERLIN GMBH,BERLIN,GERMANY

来源：

NEUROPSYCHOPHARMACOLOGY | 1997年 / 16卷 / 01期

关键词：

lithium; carbamazepine; thyroid hormones; deiodinases; rat brain;

D O I：

10.1016/S0893-133X(96)00144-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of lithium (LI) and carbamazepine (CBM) on thyroid hormone metabolism were investigated in 11 regions of the brain and three peripheral tissues in rats decapitated at three different times of day (4:00 A.M., 1:00 P.M., and 8:00 P.M.). Interest was focused on the changes in the two enzymes that catalyze: (1) the 5'deiodination of T-4 to the biologically active T-3, i.e., type II 5'deiodinase (5'D-II) and (2) the 5 (or inner-ring) deiodination of T-3 to the biologically inactive 3'3-T-2, i.e., type III 5 deiodinase (5D-III). A 14-day treatment with both LI and CBM induced significant reductions in 5D-III activity. However, 5'D-II activity was elevated by CBM and reduced by LI, both administered in concentrations leading to serum levels comparable with those seen in the prophylactic treatment of affective disorders. The effects were dose dependent, varied according to the region of the brain under investigation, and strongly depended on the time of death within the 24-hour rhythm. The consequences of these complex effects of LI and CBM on deiodinase activities for thyroid hormone function in the CNS and also their possible involvement in the mechanisms underlying the mood-stabilizing effects of both LI and CBM remain to be investigated.

引用

页码：25 / 41

页数：17

共 95 条

[21] Phenolic and tyrosyl ring iodothyronine deiodination and thyroid hormone concentrations in the human central nervous system [J].