Median nerve somatosensory evoked potentials in migraine

被引:83
作者
Ozkul, Y [1 ]
Uckardes, A [1 ]
机构
[1] Univ Harran, Fac Med, Dept Neurol, Sanliurfa, Turkey
关键词
habituation; migraine; pathophysiology; potentiation; somatosensory evoked potential;
D O I
10.1046/j.1468-1331.2002.00387.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In visual evoked potential studies, habituation during stimulus repetition with the same stimulus at a constant intensity has been found to be abnormal in migraineurs between attacks. The purpose of this study was to investigate habituation of somatosensory evoked potentials (SEPs) and the effects of migraine on them. Eighty-five subjects were included in the study: 30 healthy volunteers (HVs) and 55 migraineurs [30 with migraine without aura (MO), 25 with migraine with aura (MA)]. During continuous stimulation at 3 Hz, four blocks of 100 responses were sequentially averaged of Erb's point (N9), cervical (N13), and cortical (N20) median nerve SEPs. Mean amplitude changes in the second, third and fourth blocks are expressed as percentages of the first block. There was habituation to N13 and N20 in the second, third and fourth blocks in HVs. In the migraine groups, there was no habituation; on the contrary, potentiation was found. This potentiation was statistically significant only in the second blocks for N13 (MO P =0.007, MA P =0.01 versus HVs). However, in both migraineur groups, the rate of N20 potentiations was statistically significant versus that in HVs for all blocks (all P < 0.05). It is concluded that whilst physiological habituation occurs in HVs for cervical and cortical SEPs, in migraine patients there is an interictal deficit of habituation of this sensory modality.
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页码:227 / 232
页数:6
相关论文
共 22 条
[1]   Interictal cortical excitability in migraine:: A study using transcranial magnetic stimulation of motor and visual cortices [J].
Afra, J ;
Mascia, A ;
Gérard, P ;
de Noordhout, AM ;
Schoenen, J .
ANNALS OF NEUROLOGY, 1998, 44 (02) :209-215
[2]   Visual evoked potentials during long periods of pattern-reversal stimulation in migraine [J].
Afra, J ;
Cecchini, AP ;
De Pasqua, V ;
Albert, A ;
Schoenen, J .
BRAIN, 1998, 121 :233-241
[3]   Influence of colors on habituation of visual evoked potentials in patients with migraine with aura and in healthy volunteers [J].
Afra, J ;
Ambrosini, A ;
Genicot, R ;
Albert, A ;
Schoenen, J .
HEADACHE, 2000, 40 (01) :36-40
[4]   Comparison of visual and auditory evoked cortical potentials in migraine patients between attacks [J].
Afra, J ;
Cecchini, AP ;
Sándor, PS ;
Schoenen, J .
CLINICAL NEUROPHYSIOLOGY, 2000, 111 (06) :1124-1129
[5]   Reduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: another indication of abnormal sensory processing? [J].
Ambrosini, A ;
De Pasqua, V ;
Afra, J ;
Sandor, PS ;
Schoenen, J .
NEUROSCIENCE LETTERS, 2001, 306 (1-2) :132-134
[6]   Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine [J].
Aurora, SK ;
Ahmad, BK ;
Welch, KMA ;
Bhardhwaj, P ;
Ramadan, NM .
NEUROLOGY, 1998, 50 (04) :1111-1114
[7]   STIMULUS INTENSITY CONTROL AND CORTICAL EVOKED RESPONSE [J].
BUCHSBAUM, M ;
SILVERMAN, J .
PSYCHOSOMATIC MEDICINE, 1968, 30 (01) :12-+
[8]   GENERATOR SOURCES OF MEDIAN SOMATOSENSORY EVOKED-POTENTIALS [J].
EMERSON, RG ;
PEDLEY, TA .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1984, 1 (02) :203-218
[9]  
Fields HL., 1999, TXB PAIN
[10]   MIGRAINE PATIENTS EXHIBIT ABNORMALITIES IN THE VISUAL EVOKED-POTENTIAL [J].
GAWEL, M ;
CONNOLLY, JF ;
ROSE, FC .
HEADACHE, 1983, 23 (02) :49-52