Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats

被引:8
作者
Singh, JPV [1 ]
Selvendiran, K [1 ]
Banu, SM [1 ]
Padmavathi, R [1 ]
Sakthisekaran, D [1 ]
机构
[1] Univ Madras, Dr ALM Post Grad Inst Basic Med Sci, Dept Med Biochem, Madras 600113, Tamil Nadu, India
关键词
apigenin; antioxidants; N-nitrosodiethylamine; hepatocarcinogenesis;
D O I
暂无
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Apigenin, a dietary plant derived flavone subclass of flavonoid is expected to play a role in cancer chemoprevention and cancer chemotherapy. Here we designed our experiment to establish whether treatment of apigenin (25 mg/kg body weight) for 14 consecutive days to (N-nitrosodiethylamine) DEN induced (200 mg/kg body weight; by single ip. injection) and phenobarbital promoted (0.05% through drinking water for 14 successive weeks) rats provide protection against the oxidative stress caused by the carcinogen. The level of lipid peroxidation (LPO) markedly increased in carcinogen administered animals, which was brought back to near normal by apigenin treatment. In contrast the activities/levels of the antioxidant status both in liver and kidney were decreased in carcinogen administered animals, which was recouped back to near normal upon apigenin administration. From our findings we concluded that apigenin prevents LPO and protects antioxidant system in DEN induced and phenobarbital promoted hepatocellular carcinogenesis.
引用
收藏
页码:309 / 314
页数:6
相关论文
共 51 条
[1]   Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I [J].
Boege, F ;
Straub, T ;
Kehr, A ;
Boesenberg, C ;
Christiansen, K ;
Andersen, A ;
Jakob, F ;
Kohrle, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (04) :2262-2270
[2]   OXIDANT-INDUCED ACTIVATION OF PROTEIN-KINASE-C IN UC11MG CELLS [J].
BRAWN, MK ;
CHIOU, WJ ;
LEACH, KL .
FREE RADICAL RESEARCH, 1995, 22 (01) :23-37
[3]  
CASGRANDE F, 2001, BIOCHEM PHARMACOL, V61, P1205
[4]   Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells [J].
Chaumontet, C ;
Droumaguet, C ;
Bex, V ;
Heberden, C ;
GaillardSanchez, I ;
Martel, P .
CANCER LETTERS, 1997, 114 (1-2) :207-210
[5]   INHIBITORY EFFECTS OF PHENOLIC-COMPOUNDS ON CCL4-INDUCED MICROSOMAL LIPID-PEROXIDATION [J].
CHOLBI, MR ;
PAYA, M ;
ALCARAZ, MJ .
EXPERIENTIA, 1991, 47 (02) :195-199
[6]   LIPID-PEROXIDATION IN ERYTHROCYTES [J].
CLEMENS, MR ;
WALLER, HD .
CHEMISTRY AND PHYSICS OF LIPIDS, 1987, 45 (2-4) :251-268
[7]   Cancer - A radical approach to treatment [J].
Cleveland, JL ;
Kastan, MB .
NATURE, 2000, 407 (6802) :309-311
[8]  
DESAI ID, 1984, METHOD ENZYMOL, V105, P138, DOI 10.1016/S0076-6879(84)05019-9
[9]   Apigenin -: strong cytostatic in vitro contrasted by lack of and anti-angiogenic action efficacy in vivo [J].
Engelmann, C ;
Blot, E ;
Panis, Y ;
Bauer, S ;
Trochon, V ;
Nagy, HJ ;
Lu, H ;
Soria, C .
PHYTOMEDICINE, 2002, 9 (06) :489-495
[10]   CHEMISTRY AND BIOCHEMISTRY OF 4-HYDROXYNONENAL, MALONALDEHYDE AND RELATED ALDEHYDES [J].
ESTERBAUER, H ;
SCHAUR, RJ ;
ZOLLNER, H .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 11 (01) :81-128