Cancer - A radical approach to treatment

被引：45

作者：

Cleveland, JL

Kastan, MB

机构：

[1] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38018 USA

[2] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38018 USA

来源：

NATURE | 2000年 / 407卷 / 6802期

关键词：

D O I：

10.1038/35030277

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A compound that kills leukaemia cells does so by inhibiting an enzyme that keeps down the level of toxic reactive oxygen species. The result raises hope that this compound, together with substances that increase the concentration of these oxygen species, may be useful in treating some cancers.

引用

页码：309 / 311

页数：4

共 8 条

[1] SYNTHESIS, ANTITUBULIN AND ANTIMITOTIC ACTIVITY, AND CYTOTOXICITY OF ANALOGS OF 2-METHOXYESTRADIOL, AN ENDOGENOUS MAMMALIAN METABOLITE OF ESTRADIOL THAT INHIBITS TUBULIN POLYMERIZATION BY BINDING TO THE COLCHICINE BINDING-SITE [J].