Cancer - A radical approach to treatment

被引:45
作者
Cleveland, JL
Kastan, MB
机构
[1] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38018 USA
[2] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38018 USA
关键词
D O I
10.1038/35030277
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A compound that kills leukaemia cells does so by inhibiting an enzyme that keeps down the level of toxic reactive oxygen species. The result raises hope that this compound, together with substances that increase the concentration of these oxygen species, may be useful in treating some cancers.
引用
收藏
页码:309 / 311
页数:4
相关论文
共 8 条
[1]   SYNTHESIS, ANTITUBULIN AND ANTIMITOTIC ACTIVITY, AND CYTOTOXICITY OF ANALOGS OF 2-METHOXYESTRADIOL, AN ENDOGENOUS MAMMALIAN METABOLITE OF ESTRADIOL THAT INHIBITS TUBULIN POLYMERIZATION BY BINDING TO THE COLCHICINE BINDING-SITE [J].
CUSHMAN, M ;
HE, HM ;
KATZENELLENBOGEN, JA ;
LIN, CM ;
HAMEL, E .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (12) :2041-2049
[2]  
Davies KJA, 1995, BIOCHEM SOC SYMP, P1, DOI 10.1042/bss0610001
[3]  
FOTSIS T, 1994, NATURE, V368, P237, DOI 10.1038/368237a0
[4]   Superoxide dismutase as a target for the selective killing of cancer cells [J].
Huang, P ;
Feng, L ;
Oldham, EA ;
Keating, MJ ;
Plunkett, W .
NATURE, 2000, 407 (6802) :390-395
[5]  
Klauber N, 1997, CANCER RES, V57, P81
[6]   Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol [J].
Mukhopadhyay, T ;
Roth, JA .
ONCOGENE, 1997, 14 (03) :379-384
[7]   REQUIREMENT FOR GENERATION OF H2O2 FOR PLATELET-DERIVED GROWTH-FACTOR SIGNAL-TRANSDUCTION [J].
SUNDARESAN, M ;
YU, ZX ;
FERRANS, VJ ;
IRANI, K ;
FINKEL, T .
SCIENCE, 1995, 270 (5234) :296-299
[8]   Induction of mammalian cell transformation and genotoxicity by 2-methoxyestradiol, an endogenous metabolite of estrogen [J].
Tsutsui, T ;
Tamura, Y ;
Hagiwara, M ;
Miyachi, T ;
Hikiba, H ;
Kubo, C ;
Barrett, JC .
CARCINOGENESIS, 2000, 21 (04) :735-740