Eating to exit: autophagy-enabled senescence revealed

被引：76

作者：

White, Eileen ^{[1
,2
]}

Lowe, Scott W. ^{[1
,3
]}

机构：

[1] Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[2] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

[3] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 07期

关键词：

Senescence; autophagy; oncogene; ONCOGENE-INDUCED SENESCENCE; CELL-SURVIVAL; SUPPRESSION; BIOLOGY; P53;

D O I：

10.1101/gad.1795309

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Autophagy and senescence are two distinct cellular responses to stress that are also tumor suppression mechanisms. In this issue of Genes & Development, Young and colleagues ( pp. 798-803) discovered that autophagy is induced during and facilitates the process of senescence. Knowing now that these two pathways are functionally intertwined sets the stage for establishing how they function cooperatively in the cancer setting.

引用

页码：784 / 787

页数：4

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