Effects of morphine on oedema and tissue concentration of nerve growth factor in experimental inflammation of the rat paw

被引:16
作者
Amann, R [1 ]
Lanz, L [1 ]
Schuligoi, R [1 ]
机构
[1] Karl Franzens Univ Graz, Inst Expt & Clin Pharmacol, A-8010 Graz, Austria
关键词
nerve growth factor; non-steroidal anti-inflammatory drugs; opioid;
D O I
10.1159/000063800
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Injection of carrageenan (1 mg) into the rat hind paw caused a time-dependent increase in paw volume that was maximal 3 h after injection. At this time, the concentration of nerve growth factor (NGF) in the skin of the inflamed paw was more than twofold higher than in the contralateral, non-inflamed paw. Treatment of rats with indomethacin reduced inflammatory oedema by 57%, morphine treatment attenuated oedema by 62%. While indomethacin had no statistically significant effect on the concentration of NGF in the skin of inflamed paws, morphine attenuated the NGF response by 24.2% in a naloxone reversible manner. These data suggest that drug-induced inhibition of inflammatory oedema is not predictive of its effect on an inflammation-induced rise in tissue NGF. Furthermore, our results confirm and extend previous observations suggesting an anti-inflammatory activity of morphine. Introduction Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码:169 / 172
页数:4
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