Effects of fibroblast growth factor 21 on the heart

被引：80

作者：

Tanajak, Pongpan ^{[1
,2
]}

Chattipakorn, Siriporn C. ^{[1
,3
,4
]}

Chattipakorn, Nipon ^{[1
,2
,3
]}

机构：

[1] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand

[2] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand

[3] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand

[4] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand

来源：

JOURNAL OF ENDOCRINOLOGY | 2015年 / 227卷 / 02期

关键词：

fibroblast growth factor 21; myocardial injury; cardiac metabolism; oxidative stress; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE; BETA-KLOTHO; ADIPOSE-TISSUE; FGF21; METABOLISM; EXPRESSION; LIVER; ACTIVATION; APOPTOSIS;

D O I：

10.1530/JOE-15-0289

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Fibroblast growth factor 21 (FGF21) is a novel polypeptide ligand that has been shown to be involved in several physiological and pathological processes including regulation of glucose and lipids as well as reduction of arteriosclerotic plaque formation in the great vessels. It has also been shown to exert cardioprotective effects in myocardial infarction, cardiac ischemia-reperfusion injury, cardiac hypertrophy and diabetic cardiomyopathy. Moreover, FGF21 protects the myocardium and great arteries by attenuating remodeling, inflammation, oxidative stress and also promoting the energy supply to the heart through fatty acid beta-oxidation. This growing evidence emphasizes the important roles of FGF21 in cardioprotection. This review comprehensively summarizes and discusses the consistent and inconsistent findings regarding the beneficial effects of FGF21 on the heart available from both basic research and clinical reports. The details of the signaling, biological and pharmacological effects of FGF21 with regard to its protection of the heart are also presented and discussed in this review.

引用

页码：R13 / R30

页数：18

共 50 条

[1]

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis [J].