Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies

被引：14

作者：

Miller, ML

Roller, EE

Wu, XY

Leece, BA

Goldmacher, VS

Chari, RVJ

Ojima, I

机构：

[1] ImmunoGen Inc, Cambridge, MA 02139 USA

[2] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期

关键词：

taxoid; antibody conjugate; tumor specific; targeted delivery;

D O I：

10.1016/j.bmcl.2004.05.027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The targeted delivery of taxoids, in the form of taxane-antibody immunoconjugates, requires the preparation of taxoids containing moieties suitable for their conjugation to monoclonal antibodies. A series of taxoids incorporating a disulfide-containing linker at various positions of the taxoid framework have been prepared to investigate the most suitable position for conjugation. A second series of taxoids modified at the C-2 position aimed at increasing the potency of these taxanes has also been prepared. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4079 / 4082

页数：4

共 20 条

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