Transcriptional mechanisms in the development of motor control

被引：42

作者：

Jurata, LW

Thomas, JB

Pfaff, SL

机构：

[1] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

[2] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2000年 / 10卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(99)00053-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Considerable progress has been made in understanding how combinatorially expressed transcription factors control the development of neuronal subtypes in the fly and vertebrate central nervous systems. The mode of action of many of these factors has been conserved from invertebrates to vertebrates throughout evolution, such as the formation and regulation of specific transcriptional complexes, the utilization of repressors for maintaining specificity, and the use of phosphorylation as an important means for transiently altering transcriptional activity.

引用

页码：72 / 79

页数：8

共 59 条

[1] Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity [J].