Oncogenic γ-herpesviruses:: Comparison of viral proteins involved in tumorigenesis

被引：104

作者：

Damania, B ^{[1
]}

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2004年 / 2卷 / 08期

关键词：

D O I：

10.1038/nrmicro958

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpesviruses are present in most species throughout the animal kingdom and are classified into three subfamilies, alpha, beta and gamma, on the basis of their biological properties and genome sequences. A striking feature that is shared by many of the gamma-herpesviruses is their ability to induce neoplastic disease in the host. This review focuses on three gamma-herpesviruses: Epstein - Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and herpesvirus saimiri (HVS), and discusses the diverse array of EBV, KSHV and HVS viral genes that are involved in transformation, cell signalling, episomal maintenance and cell proliferation.

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页码：656 / 668

页数：13

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