A Facile Route for Regioselective Conjugation of Organo-Soluble Polymers onto Chitosan

被引：48

作者：

Cai, Guoqiang ^{[1
,2
]}

Jiang, Hongliang ^{[1
,2
]}

Tu, Kehua ^{[1
,2
]}

Wang, Liqun ^{[1
,2
]}

Zhu, Kangjie ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Minist Educ, Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2009年 / 9卷 / 03期

基金：

中国国家自然科学基金;

关键词：

chitosan; graft copolymers; modification; NMR; surfactants; POLY(ETHYLENE GLYCOL); DERIVATIVES;

D O I：

10.1002/mabi.200800153

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A facile route is described for the regioselective conjugation of organo-soluble polymers onto chitosan under very mild conditions, using SCC as intermediates. SCC could be prepared simply by mixing chitosan acidic aqueous solution with SDS. PEG or PCL were then grafted to SCC using the NHS/DCC coupling method. In addition, the polymers were found to be linked to chitosan through the hydroxyl groups of chitosan when stoichiometric SCC was used as a precursor. SDS could be removed simply by either precipitating the solution of SCC-graft-polymer in DMSO into Tris aqueous solution or dialyzing against Tris solution.

引用

页码：256 / 261

页数：6

共 21 条

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[2]

[Anonymous], 2003, CARBOHYDRATE POLYM, DOI DOI 10.1016/S0144-8617(02)00208-4

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