CTCF: Master Weaver of the Genome

被引：1204

作者：

Phillips, Jennifer E. ^{[1
]}

Corces, Victor G. ^{[1
]}

机构：

[1] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

来源：

CELL | 2009年 / 137卷 / 07期

关键词：

IMPRINTING CONTROL REGION; BETA-GLOBIN LOCUS; CHROMOSOME CONFORMATION CAPTURE; INSULATOR PROTEIN CTCF; ENHANCER-BLOCKING ACTIVITY; ORDER CHROMATIN-STRUCTURE; THYROID-HORMONE RECEPTOR; CCCTC-BINDING FACTOR; RNA-POLYMERASE-II; C-MYC GENE;

D O I：

10.1016/j.cell.2009.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight evidence for CTCF-mediated intra- and interchromosomal contacts at several developmentally regulated genomic loci. These analyses support a primary role for CTCF in the global organization of chromatin architecture and suggest that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression. © 2009 Elsevier Inc. All rights reserved.

引用

页码：1194 / 1211

页数：18

共 100 条

[1] Virus infection induces NF-κB-dependent interchromosomal associations mediating monoallelic IFN-β gene expression [J].