Activation of the Human Contact System on Neutrophil Extracellular Traps

被引：162

作者：

Oehmcke, Sonja ^{[1
]}

Morgelin, Matthias ^{[1
]}

Herwald, Heiko ^{[1
]}

机构：

[1] Lund Univ, Dept Clin Sci, Div Infect Med, BMC, SE-22184 Lund, Sweden

来源：

JOURNAL OF INNATE IMMUNITY | 2009年 / 1卷 / 03期

基金：

瑞典研究理事会;

关键词：

Contact system; DNA-protein interaction; Immunity; Innate; Polymorphonuclear leukocytes; Streptococcus; PLASMA; PROTEIN;

D O I：

10.1159/000203700

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface that allows the binding and activation of the contact system. In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：225 / 230

页数：6

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