A limited role for DJ1 in Parkinson disease susceptibility

被引：17

作者：

Maraganore, DM

Wilkes, K

Lesnick, TG

Strain, KJ

de Andrade, M

Rocca, WA

Bower, JH

Ahlskog, JE

Lincoln, S

Farrer, MJ

机构：

[1] Mayo Clin Rochester, Dept Neurol, Rochester, MN USA

[2] Mayo Clin Rochester, Dept Hlth Sci Res, Rochester, MN USA

[3] Mayo Clin Jacksonville, Dept Neurosci, Jacksonville, FL 32224 USA

来源：

NEUROLOGY | 2004年 / 63卷 / 03期

关键词：

D O I：

10.1212/01.WNL.0000133402.78621.AD

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An association study of four common polymorphisms in the DJ1 gene and Parkinson disease (PD) was conducted. PD probands were compared with their unaffected siblings matched by gender and closest age at study (416 vs 416) and with unrelated control subjects (691 vs 190). None of the four haplotype tagging single-nucleotide polymorphisms (SNPs) was associated with PD overall, but SNP1 (position 4,345 bp) and SNP3 (position 16,491 bp) were associated with PD in women (p=0.03 and p=0.002).

引用

页码：550 / 553

页数：4

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