Synthesis of pyridopyranoquinolines by the skraup reaction of amino-5H-benzopyrano[2,3-b]pyridin-5-ones

被引：16

作者：

Fujiwara, H ^{[1
]}

Kitagawa, K ^{[1
]}

机构：

[1] Niigata Coll Pharm, Niigata 9502081, Japan

来源：

HETEROCYCLES | 2000年 / 53卷 / 02期

关键词：

Ullmann reaction; PPA cyclization; direct amination;

D O I：

10.3987/COM-99-8753

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

7-, 8- and 9-Amino-5H-[1]benzopyrano[2,3-b]-pyridin-5-ones were synthesized. Skraup reaction of 6-Amino-, 7-amino-, 8-amino- and 9-Amino-5H-[1]benzopyrano[2,3-b]pyridin-5-ones in the presence of glycerol, fuming sulfuric acid, nitrobenzene, iron(II) sulfate and boric acid gave 12H-pyrido[3',2':5,6]pyrano[2,3-h]-quinolin-12-one, 12H-pyrido[3',2':5,6]pyrano[3,2-f]-quinolin-12-one, 7H-pyrido[3',2':5,6]pyrano[2,3-f]quinolin-7-one and 7H-pyrido[3',2':5,6]pyrano[3,2-h]quinolin-7-one, respectively.

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页码：409 / +

页数：10

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