The orphanin FQ/nociceptin knockout mouse: A behavioral model for stress responses

被引：40

作者：

Reinscheid, RK ^{[1
]}

Civelli, O ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92612 USA

来源：

NEUROPEPTIDES | 2002年 / 36卷 / 2-3期

关键词：

D O I：

10.1054/npep.2002.0901

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transgenic mice lacking expression of the OFQ/N precursor protein have provided exciting insights in the physiological functions of this neuropeptide system. While injection of OFQ/N or selective synthetic agonists produces anxiolytic effects in rodents, OFQ/N knockout mice display increased anxiety and impaired adaptation to repeated stress. On the other hand, mice lacking the cognate OFQ/N receptor, ORL1, show improved spatial attention and memory but appear to have normal anxiety and stress behavior. Availability of a selective small molecule OFQ/N antagonist might help clarify this discrepancy. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：72 / 76

页数：5

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