Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors

被引：381

作者：

Jackson, CL

Casanova, JE

机构：

[1] CEA Saclay, Serv Biochim & Genet Mol, F-91191 Gif Sur Yvette, France

[2] Univ Virginia, Hlth Sci Ctr, Dept Cell Biol, Charlottesville, VA 22908 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0962-8924(99)01699-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ARF proteins are important regulators of membrane dynamics mid protein transport within the eukaryotic cell. The Sec7 domain is similar to 200 amino acids in size and stimulates guanine-nucleotide exchange on members of the ARF class of small GTPases. The members of one subclass of Sec7-domain proteins are direct targets of the secretion-inhibiting drug brefeldin A, which blocks the exchange reaction by trapping a reaction intermediate in an inactive, abortive complex. A separate subclass of Sec7-domain proteins is involved in signal transduction and possess a domain that mediates membrane binning in response to extracellular signals.

引用

收藏

页码：60 / 67

页数：8

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