Withanolide Artifacts Formed in Methanol

被引：24

作者：

Cao, Cong-Mei ^{[1
]}

Zhang, Huaping ^{[1
]}

Gallagher, Robert J. ^{[1
]}

Timmermann, Barbara N. ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 11期

关键词：

WITHANIA-SOMNIFERA; MINOR WITHANOLIDES; PHYSALIS-PERUVIANA; QUINONE REDUCTASE; VAR; FRANCHETII; CONSTITUENTS; ANGULATA; STEROIDS; PHILADELPHICA; DERIVATIVES;

D O I：

10.1021/np400296s

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Methanol solutions of the main withanolides (6-8) naturally present in Physalis longifolia yielded five artificial withanolides (1-5), including three new compounds (1-3). Withanolides 1 and 2 were identified as intramolecular Michael addition derivatives, while withanolides 3-5 were the result of intermolecular Michael addition. A comprehensive literature investigation was conducted to identify potential withanolide Michael addition artifacts isolated from Solanaceous species to date.

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页码：2040 / 2046

页数：7

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