The role of innate and lymphoid IL-22-producing cells in the immunopathology of primary Sjogren's syndrome

被引：22

作者：

Ciccia, Francesco ^{[1
]}

Guggino, Giuliana ^{[1
]}

Giardina, AnnaRita ^{[1
]}

Ferrante, Angelo ^{[1
]}

Carrubbi, Francesco ^{[2
]}

Giacomelli, Roberto ^{[2
]}

Triolo, Giovanni ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Palermo, Italy

[2] Univ Aquila, Dipartimento Sci Clin Appl & Biotecnol, Sez Reumatol, Coppito, Italy

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2014年 / 10卷 / 04期

关键词：

primary Sjogren's syndrome; epithelial cells; NK cells; innate immunity; adaptive immunity; IL-22; MESSENGER-RNA EXPRESSION; ARYL-HYDROCARBON RECEPTOR; NATURAL-KILLER-CELLS; SALIVARY-GLANDS; INTERLEUKIN; 22; INTESTINAL INFLAMMATION; EPITHELIAL-CELLS; INDUCIBLE FACTOR; RITUXIMAB TREATMENT; PERIPHERAL-BLOOD;

D O I：

10.1586/1744666X.2014.884461

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In primary Sjogren's syndrome (pSS) a complex of interconnections between epithelial barrier, innate and adaptive immunity occurs. IL-22 is a pleiotropic cytokine that in pSS may be placed at the intersection of the adaptive and innate branches of immunity. Some evidence suggests that, in pSS, IL-22 may play a prominent pro-inflammatory role driving the early phase of tissue and systemic inflammation and participating in the self-perpetuation of disease. Despite contradictory data in literature about the role of NK cells in pSS, recent data also suggest an important contribution of this subset of cells of the innate immune system in the development and perpetuation of inflammation. Here, we discuss the role of IL-22 in the pathogenesis of pSS and in epithelial barrier function.

引用

收藏

页码：533 / 541

页数：9

相关论文

共 92 条

[1]

Lineage relationships of human interleukin-22-producing CD56+ RORγt+ innate lymphoid cells and conventional natural killer cells [J].

Ahn, Yong-Oon ;

Blazar, Bruce R. ;

Miller, Jeffrey S. ;

Verneris, Michael R. .

BLOOD, 2013, 121 (12) :2234-2243

[2]

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[3]

Tight Junctions in Salivary Epithelium [J].

Baker, Olga J. .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,

[4]

Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma [J].

Bard, J. Dien ;

Gelebart, P. ;

Anand, M. ;

Amin, H. M. ;

Lai, R. .

LEUKEMIA, 2008, 22 (08) :1595-1603

[5]

CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: Association with reactive and malignant areas of lymphoid organization [J].

Barone, Francesca ;

Bombardieri, Michele ;

Rosado, Manuela Maria ;

Morgan, Peter Roger ;

Challacombe, Stephen J. ;

De Vita, Salvatore ;

Carsetti, Rita ;

Spencer, Jo ;

Valesini, Guido ;

Pitzalis, Costantino .

JOURNAL OF IMMUNOLOGY, 2008, 180 (07) :5130-5140

[6]

IL-22RA2 Associates with Multiple Sclerosis and Macrophage Effector Mechanisms in Experimental Neuroinflammation [J].

Beyeen, Amennai D. ;

Adzemovic, Milena Z. ;

Ockinger, Johan ;

Stridh, Pernilla ;

Becanovic, Kristina ;

Laaksonen, Hannes ;

Lassmann, Hans ;

Harris, Robert A. ;

Hillert, Jan ;

Alfredsson, Lars ;

Celius, Elisabeth G. ;

Harbo, Hanne F. ;

Kockum, Ingrid ;

Jagodic, Maja ;

Olsson, Tomas .

JOURNAL OF IMMUNOLOGY, 2010, 185 (11) :6883-6890

[7]

Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjogren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate [J].

Bombardieri, M ;

Barone, F ;

Pittoni, V ;

Alessandri, C ;

Conigliaro, P ;

Blades, MC ;

Priori, R ;

McInnes, IB ;

Valesini, G ;

Pitzalis, C .

ARTHRITIS RESEARCH & THERAPY, 2004, 6 (05) :R447-R456

[8]

A role for T cell-derived interleukin 22 in psoriatic skin inflammation [J].

Boniface, K. ;

Guignouard, E. ;

Pedretti, N. ;

Garcia, M. ;

Delwail, A. ;

Bernard, F. -X. ;

Nau, F. ;

Guillet, G. ;

Dagregorio, G. ;

Yssel, H. ;

Lecron, J. -C. ;

Morel, F. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 150 (03) :407-415

[9]

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity [J].

Cella, Marina ;

Fuchs, Anja ;

Vermi, William ;

Facchetti, Fabio ;

Otero, Karel ;

Lennerz, Jochen K. M. ;

Doherty, Jason M. ;

Mills, Jason C. ;

Colonna, Marco .

NATURE, 2009, 457 (7230) :722-725

[10]

Rituximab modulates the expression of IL-22 in the salivary glands of patients with primary Sjogren's syndrome [J].

Ciccia, Francesco ;

Giardina, AnnaRita ;

Rizzo, Aroldo ;

Guggino, Giuliana ;

Cipriani, Paola ;

Carubbi, Francesco ;

Giacomelli, Roberto ;

Triolo, Giovanni .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (05) :782-783

← 1 2 3 4 5 6 7 8 9 10 →