Resistance-modifying agents.: Part 7:: 2, 6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)

被引：10

作者：

Barlow, HC

Bowman, KJ

Curtin, NJ

Calvert, AH

Golding, BT

Huang, B

Loughlin, PJ

Newell, DR

Smith, PG

Griffin, RJ

机构：

[1] Univ Newcastle Upon Tyne, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Med Sch Newcastle Upon Tyne, Canc Res Unit, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)00053-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to alpha(1)-acid glycoprotein, is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：585 / 589

页数：5

共 19 条

[1]

BELT JA, 1993, ADV ENZYME REGUL, V33, P235

[2]

BUDD GT, 1990, CANCER RES, V50, P7206

[3]

Buolamwini JK, 1997, CURR MED CHEM, V4, P35

[4] Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein binding [J].

Curtin, NJ ;

Bowman, KJ ;

Turner, RN ;

Huang, B ;

Loughlin, PJ ;

Calvert, AH ;

Golding, BT ;

Griffin, RJ ;

Newell, DR .

BRITISH JOURNAL OF CANCER, 1999, 80 (11) :1738-1746

[5] MODULATION OF DIPYRIDAMOLE ACTION BY ALPHA-1-ACID GLYCOPROTEIN - REDUCED POTENTIATION OF QUINAZOLINE ANTIFOLATE (CB3717) CYTO-TOXICITY BY DIPYRIDAMOLE [J].

CURTIN, NJ ;

NEWELL, DR ;

HARRIS, AL .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (19) :3281-3288

[6] NUCLEOSIDE SALVAGE AND RESISTANCE TO ANTIMETABOLITE ANTICANCER AGENTS [J].

FOX, M ;

BOYLE, JM ;

KINSELLA, AR .

BRITISH JOURNAL OF CANCER, 1991, 64 (03) :428-436

[7]

GOEL R, 1992, NEW DRUGS CONCEPTS R, P19

[8] Folate-based thymidylate synthase inhibitors as anticancer drugs [J].

Jackman, AL ;

Calvert, AH .

ANNALS OF ONCOLOGY, 1995, 6 (09) :871-881

[9] MODULATION OF ANTI-METABOLITE EFFECTS - EFFECTS OF THYMIDINE ON THE EFFICACY OF THE QUINAZOLINE-BASED THYMIDYLATE SYNTHETASE INHIBITOR, CB3717 [J].

JACKMAN, AL ;

TAYLOR, GA ;

CALVERT, AH ;

HARRAP, KR .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (20) :3269-3275

[10]

KREMER JMH, 1988, PHARMACOL REV, V40, P1

← 1 2 →