Resistance-modifying agents.: Part 7:: 2, 6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)

被引：10

作者：

Barlow, HC

Bowman, KJ

Curtin, NJ

Calvert, AH

Golding, BT

Huang, B

Loughlin, PJ

Newell, DR

Smith, PG

Griffin, RJ

机构：

[1] Univ Newcastle Upon Tyne, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Med Sch Newcastle Upon Tyne, Canc Res Unit, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)00053-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to alpha(1)-acid glycoprotein, is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：585 / 589

页数：5

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