Highly selective oligonucleotide-based sensor for mercury(II) in aqueous solutions

被引：1144

作者：

Ono, A ^{[1
]}

Togashi, H ^{[1
]}

机构：

[1] Tokyo Metropolitan Univ, Grad Sch Sci, Dept Chem, Hachioji, Tokyo 1920397, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 33期

关键词：

biosensors; fluorescence; FRET (fluorescence resonance energy transfer); mercury; oligonucleotides;

D O I：

10.1002/anie.200454172

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mercury gauge: An oligodeoxyribonucleotide(ODN)-based sensor, which carries energy-donor and -acceptor moieties (fluorescein, F, and dabcyl, D, respectively), selectively detects HgII ions in aqueous solution. Upon binding HgII ions, the ODN takes on a hairpin structure (see picture); this results in a decrease in the fluorescence emission through enhanced FRET (fluorescence resonance energy transfer) from F to D.

引用

页码：4300 / 4302

页数：3

共 53 条

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