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Thermal melting studies with PNA and PNA-DNA chimera

被引：7
作者：
Kuimelis, RG
van der Laan, AC
Vinayak, R
机构：
[1] PE Biosyst, Foster City, CA 94404 USA
[2] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 43期
关键词：
D O I：
10.1016/S0040-4039(99)01586-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have performed thermal melting studies towards developing an empirical formula for PNA-DNA duplexes. Our results indicate the identity and sequence of the junction between the phosphodiester and 2-aminoethylglycine backbones are critical to the overall stability of the duplex and an important design consideration. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7671 / 7674
页数：4
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