A convenient automated solid-phase synthesis of PNA-(5')-DNA-(3')-PNA chimera

被引：43

作者：

vanderLaan, AC

Brill, R

Kuimelis, RG

KuylYeheskiely, E

vanBoom, JH

Andrus, A

Vinayak, R

机构：

[1] LEIDEN UNIV, LEIDEN INST CHEM, NL-2300 RA LEIDEN, NETHERLANDS

[2] PERKIN ELMER CORP, APPL BIOSYST, FOSTER CITY, CA 94404 USA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(97)00344-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An automated online solid-phase synthesis of Ac-cac ct T*GG TC t*ac ct-Gly-OH1 using standard DNA and appropriately protected PNA building blocks (2-5) is described. This chimera forms stable duplexes with complementary DNA and RNA. (C) 1997 Elsevier Science Ltd.

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页码：2249 / 2252

页数：4

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