A convenient automated solid-phase synthesis of PNA-(5')-DNA-(3')-PNA chimera

被引:43
作者
vanderLaan, AC
Brill, R
Kuimelis, RG
KuylYeheskiely, E
vanBoom, JH
Andrus, A
Vinayak, R
机构
[1] LEIDEN UNIV, LEIDEN INST CHEM, NL-2300 RA LEIDEN, NETHERLANDS
[2] PERKIN ELMER CORP, APPL BIOSYST, FOSTER CITY, CA 94404 USA
关键词
D O I
10.1016/S0040-4039(97)00344-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An automated online solid-phase synthesis of Ac-cac ct T*GG TC t*ac ct-Gly-OH1 using standard DNA and appropriately protected PNA building blocks (2-5) is described. This chimera forms stable duplexes with complementary DNA and RNA. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:2249 / 2252
页数:4
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