THE SYNTHESIS OF POLYAMIDE NUCLEIC-ACIDS USING A NOVEL MONOMETHOXYTRITYL PROTECTING-GROUP STRATEGY

被引：110

作者：

WILL, DW ^{[1
]}

LANGNER, D ^{[1
]}

KNOLLE, J ^{[1
]}

UHLMANN, E ^{[1
]}

机构：

[1] HOECHST AG,ALLGEMEINE PHARMA FORSCH G838,D-65926 FRANKFURT,GERMANY

来源：

TETRAHEDRON | 1995年 / 51卷 / 44期

关键词：

D O I：

10.1016/0040-4020(95)00766-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of novel monomethoxytrityl (Mmt) protected monomers for the synthesis of polyamide nucleic acids (PNAs) is described. The use of base-labile acyl-type nucleobase protecting groups and of a succinyl-linked solid-support offers a synthetic strategy similar to standard oligonucleotide synthesis conditions. This strategy has been successfully applied for the synthesis of PNAs of mixed base sequence.

引用

页码：12069 / 12082

页数：14

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