Low-dose subcutaneous ketamine infusion and morphine tolerance

被引：66

作者：

Bell, RF ^{[1
]}

机构：

[1] Haukeland Univ Hosp, Dept Anaesthesiol & Intens Care, Pain Clin, N-5021 Bergen, Norway

来源：

PAIN | 1999年 / 83卷 / 01期

关键词：

NMDA receptor; tolerance; ketamine; morphine; infusion;

D O I：

10.1016/S0304-3959(99)00096-2

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The NMDA receptor has been reported to be involved in opioid tolerance. Adjuvant subcutaneous infusion treatment with (very) low-dose ketamine, a NMDA receptor antagonist, improves analgesia and at the same time appears to reduce morphine tolerance. Three cases are presented. (C) 1999 International Association for the Study of Pain. Published by Elsevier Science B.V.

引用

页码：101 / 103

页数：3

共 11 条

[1] EFFECTIVE TREATMENT OF SEVERE CANCER PAIN OF THE HEAD USING LOW-DOSE KETAMINE IN AN OPIOID-TOLERANT PATIENT [J].

CLARK, JL ;

KALAN, GE .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 1995, 10 (04) :310-314

[2] Decrease of tolerance to, and physical dependence on morphine by, glutamate receptor antagonists [J].

Gonzalez, P ;

Cabello, P ;

Germany, A ;

Norris, B ;

Contreras, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 332 (03) :257-262

[3]

HERMAN BH, 1995, NEUROPSYCHOPHARMACOL, V13, P269, DOI 10.1016/0893-133X(95)00140-9

[4] The NMDA receptor competitive antagonist CPP modulates benzodiazepine tolerance and discontinuation [J].

Koff, JM ;

Pritchard, GA ;

Greenblatt, DJ ;

Miller, LG .

PHARMACOLOGY, 1997, 55 (05) :217-227

[5]

Kolesnikov Y, 1998, J PHARMACOL EXP THER, V284, P455

[6]

KOYUNCUOGLU H, 1995, INT J CLIN PHARM TH, V33, P13

[7] MECHANISMS OF HYPERALGESIA AND MORPHINE-TOLERANCE - A CURRENT VIEW OF THEIR POSSIBLE INTERACTIONS [J].

MAO, JR ;

PRICE, DD ;

MAYER, DJ .

PAIN, 1995, 62 (03) :259-274

[8] Oral administration of dextromethorphan prevents the development of morphine tolerance and dependence in rats [J].

Mao, JR ;

Price, DD ;

Caruso, FS ;

Mayer, DJ .

PAIN, 1996, 67 (2-3) :361-368

[9]

Mayer D J, 1995, NIDA Res Monogr, V147, P269

[10] PERSPECTIVES ON THE N-METHYL-D-ASPARTATE NITRIC-OXIDE CASCADE AND OPIOID TOLERANCE [J].

PASTERNAK, GW ;

KOLESNIKOV, YA ;

BABEY, AM .

NEUROPSYCHOPHARMACOLOGY, 1995, 13 (04) :309-313

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