Activation of glucokinase gene expression by hepatic nuclear factor 4α in primary hepatocytes

被引：36

作者：

Roth, U ^{[1
]}

Jungermann, K ^{[1
]}

Kietzmann, T ^{[1
]}

机构：

[1] Univ Gottingen, Inst Biochem & Mol Zellbiol, D-37073 Gottingen, Germany

来源：

BIOCHEMICAL JOURNAL | 2002年 / 365卷 / 01期

关键词：

glycolysis; hypoxia; insulin; maturity-onset diabetes of the young; metabolic zonation; nuclear receptor;

D O I：

10.1042/BJ20020340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO(2) enhanced HNF-4 levels and binding to the GK-HNF-4 element. Thus, HNF-4alpha could play the role of a regulator for zonated GK expression.

引用

页码：223 / 228

页数：6

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