1-(dihydroxyphosphynyl)vinyl phosphate: The phosphonate analogue of phosphoenolpyruvate is a pH-dependent substrate of Kdo8P synthase

被引：11

作者：

Benenson, Y ^{[1
]}

Belakhov, V ^{[1
]}

Baasov, T ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL,DEPT CHEM,IL-32000 HAIFA,ISRAEL

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(96)00539-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The phosphonate analogue of PEP (structure 5), in which the carboxylate group is replaced by an isosteric phosphonate, was synthesized and evaluated as a substrate and as an inhibitor of the KdoSP synthase. It was demonstrated that 5 is a very slow, pH-dependent substrate of the enzyme. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2901 / 2906

页数：6

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