Lipoprotein receptors: new roles for ancient proteins

被引：176

作者：

Willnow, TE

Nykjaer, A

Herz, J

机构：

[1] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

[2] Aarhus Univ, Dept Biochem Med, DK-8000 Aarhus, Denmark

[3] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75235 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 06期

关键词：

D O I：

10.1038/14109

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lipoprotein receptors used to be viewed simply as the means by which cells were supplied with lipids for energy production and membrane synthesis. This perception has now changed dramatically. Megalin, a member of the low density lipoprotein receptor gene family, turns out to mediate the endocytic uptake of retinoids and steroids, thus helping to regulate their biological function. Other members of this receptor family interact with cytosolic signalling proteins, giving this evolutionarily ancient family of receptors an entirely unexpected new role as transducers of extracellular signals.

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页码：E157 / E162

页数：6

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