Lipoprotein receptors: new roles for ancient proteins

被引：176

作者：

Willnow, TE

Nykjaer, A

Herz, J

机构：

[1] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany

[2] Aarhus Univ, Dept Biochem Med, DK-8000 Aarhus, Denmark

[3] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75235 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 06期

关键词：

D O I：

10.1038/14109

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lipoprotein receptors used to be viewed simply as the means by which cells were supplied with lipids for energy production and membrane synthesis. This perception has now changed dramatically. Megalin, a member of the low density lipoprotein receptor gene family, turns out to mediate the endocytic uptake of retinoids and steroids, thus helping to regulate their biological function. Other members of this receptor family interact with cytosolic signalling proteins, giving this evolutionarily ancient family of receptors an entirely unexpected new role as transducers of extracellular signals.

引用

收藏

页码：E157 / E162

页数：6

相关论文

共 74 条

[31] Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway [J].

Hsu, HY ;

Hajjar, DP ;

Khan, KMF ;

Falcone, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (02) :1240-1246

[32] HYPERCHOLESTEROLEMIA IN LOW-DENSITY-LIPOPROTEIN RECEPTOR KNOCKOUT MICE AND ITS REVERSAL BY ADENOVIRUS-MEDIATED GENE DELIVERY [J].

ISHIBASHI, S ;

BROWN, MS ;

GOLDSTEIN, JL ;

GERARD, RD ;

HAMMER, RE ;

HERZ, J .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (02) :883-893

[33] Sequence and functional relationships between androgen-binding protein sex hormone-binding globulin and its homologs protein S, Gas6, laminin, and agrin [J].

Joseph, DR .

STEROIDS, 1997, 62 (8-9) :578-588

[34] Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease [J].

Kang, DE ;

Saitoh, T ;

Chen, X ;

Xia, Y ;

Masliah, E ;

Hansen, LA ;

Thomas, RG ;

Thal, LJ ;

Katzman, R .

NEUROLOGY, 1997, 49 (01) :56-61

[35] Human apolipoprotein E receptor 2 - A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain [J].

Kim, DH ;

Iijima, H ;

Goto, K ;

Sakai, J ;

Ishii, H ;

Kim, HJ ;

Suzuki, H ;

Kondo, H ;

Saeki, S ;

Yamamoto, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (14) :8373-8380

[36] HEPATIC-UPTAKE OF CHYLOMICRON REMNANTS IN WHHL RABBITS - A MECHANISM GENETICALLY DISTINCT FROM THE LOW-DENSITY LIPOPROTEIN RECEPTOR [J].

KITA, T ;

GOLDSTEIN, JL ;

BROWN, MS ;

WATANABE, Y ;

HORNICK, CA ;

HAVEL, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3623-3627

[37] Essential roles for the Abl and Arg tyrosine kinases in neurulation [J].

Koleske, AJ ;

Gifford, AM ;

Scott, ML ;

Nee, M ;

Bronson, RT ;

Miczek, KA ;

Baltimore, D .

NEURON, 1998, 21 (06) :1259-1272

[38] LDL RECEPTOR-RELATED PROTEIN, A MULTIFUNCTIONAL APOE RECEPTOR, BINDS SECRETED BETA-AMYLOID PRECURSOR PROTEIN AND MEDIATES ITS DEGRADATION [J].

KOUNNAS, MZ ;

MOIR, RD ;

REBECK, GW ;

BUSH, AI ;

ARGRAVES, WS ;

TANZI, RE ;

HYMAN, BT ;

STRICKLAND, DK .

CELL, 1995, 82 (02) :331-340

[39] STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS - MACROPHAGE SCAVENGER RECEPTORS AND LDL RECEPTOR-RELATED PROTEIN (LRP) [J].

KRIEGER, M ;

HERZ, J .

ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 :601-637

[40] EVIDENCE THAT THE NEWLY CLONED LOW-DENSITY-LIPOPROTEIN RECEPTOR RELATED PROTEIN (LRP) IS THE ALPHA-2-MACROGLOBULIN RECEPTOR [J].

KRISTENSEN, T ;

MOESTRUP, SK ;

GLIEMANN, J ;

BENDTSEN, L ;

SAND, O ;

SOTTRUPJENSEN, L .

FEBS LETTERS, 1990, 276 (1-2) :151-155

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