Standardizing a composite measure of linkage disequilibrium

被引：17

作者：

Hamilton, DC ^{[1
]}

Cole, DEC

机构：

[1] Dalhousie Univ, Dept Math & Stat, Halifax, NS B3H 3J5, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

ANNALS OF HUMAN GENETICS | 2004年 / 68卷

关键词：

D O I：

10.1046/j.1529-8817.2004.00056.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The maximum and minimum are obtained for a composite measure of linkage disequilibrium used with genotypic data when the phase of double heterozygotes cannot be determined. These bounds are used to standardize the composite measure in the same way used for D', the standardized gametic measure of linkage disequilibrium. Standardization produces a measure which lies between -1 and 1, and allows comparison of linkage disequilibrium between populations. The method is illustrated using two loci in the CASR gene.

引用

页码：234 / 239

页数：6

共 13 条

[1] Patterns of linkage disequilibrium in the human genome [J].

Ardlie, KG ;

Kruglyak, L ;

Seielstad, M .

NATURE REVIEWS GENETICS, 2002, 3 (04) :299-309

[2]

COLE DEC, 1998, BONE S1, V23

[3] ESTIMATION OF LINKAGE DISEQUILIBRIUM IN RANDOMLY MATING POPULATIONS [J].

HILL, WG .

HEREDITY, 1974, 33 (OCT) :229-239

[4]

LEWONTIN RC, 1964, GENETICS, V49, P49

[5] Candidate-gene approaches for studying complex genetic traits: practical considerations [J].

Tabor, HK ;

Risch, NJ ;

Myers, RM .

NATURE REVIEWS GENETICS, 2002, 3 (05) :391-A396

[6]

WEIR BS, 1986, GENET EPIDEMIOL, P177

[7] INFERENCES ABOUT LINKAGE DISEQUILIBRIUM [J].

WEIR, BS .

BIOMETRICS, 1979, 35 (01) :235-254

[8]

WEIR BS, 1979, HEREDITY, V42, P105, DOI 10.1038/hdy.1979.10

[9]

Weir BS., 1996, GENETIC DATA ANAL

[10]

Weir BS., 1989, Mathematical Evolutionary Theory, P86

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