Metabotropic glutamate receptors and neurodegenerative diseases

被引：210

作者：

Ribeiro, Fabiola M. ^{[1
]}

Vieira, Luciene B. ^{[2
]}

Pires, Rita G. W. ^{[3
]}

Olmo, Roenick P. ^{[1
]}

Ferguson, Stephen S. G. ^{[4
,5
]}

机构：

[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Espirito Santo, Hlth Sci Ctr, Dept Physiol Sci, BR-29043910 Vitoria, Brazil

[4] Univ Ottawa, Brain & Mind Inst, Fac Med, 451 Smyth Dr, Ottawa, ON K1H 8M5, Canada

[5] Univ Ottawa, Dept Cellular & Mol Med, Fac Med, 451 Smyth Dr, Ottawa, ON K1H 8M5, Canada

来源：

PHARMACOLOGICAL RESEARCH | 2017年 / 115卷

关键词：

Glutamate; mGluRs; Alzheimer's disease; Parkinson's disease; Huntington's disease; POSITIVE ALLOSTERIC MODULATOR; DOPA-INDUCED DYSKINESIA; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA EXPRESSION; AMYLOID-BETA PROTEIN; LONG-TERM DEPRESSION; HUNTINGTONS-DISEASE; GROUP-I; A-BETA; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.phrs.2016.11.013

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Glutamate is the most important excitatory neurotransmitter of the mammalian central nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal development. However, glutamate overstimulation is also implicated in neuronal cell death. There are two major types of glutamate receptors: ionotropic and metabotropic. Thus far, eight metabotropic glutamate receptors (mGluRs) subtypes have been characterized and are divided into three subgroups based on sequence homology and cell signaling activation. mGluRs activate a wide variety of cell signaling pathways by G protein coupled pathways or via G protein-independent cell signaling activation. Moreover, these receptors exhibit widespread distribution in the CNS and are implicated in several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). This review aims to discuss the latest updates concerning mGluRs and their role in neurodegenerative diseases. mGluRs agonists and antagonists as well as positive and negative allosteric modulators have been tested in several animal models of neurodegenerative diseases. Furthermore, mGluR knockout mouse models have been crossed to mouse models of AD and HD, providing important data about mGluRs role in neurodegenerative disease progression. Thus, mGluRs constitute potential therapeutic targets for the development of therapies to treat neurodegenerative diseases. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：179 / 191

页数：13

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