Current practical applications of diagnostic immunohistochemistry in breast pathology

被引：117

作者：

Lerwill, MF

机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, James Homer Wright Pathol Labs, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 2004年 / 28卷 / 08期

关键词：

D O I：

10.1097/01.pas.0000126780.10029.f0

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In recent years, immunohistochemistry has assumed an increasingly prominent role in diagnostic breast pathology. Immunohistochemistry is now frequently used in the evaluation of many epithelial proliferations of the breast. Common applications include the use of myoepithelial markers to evaluate for stromal invasion, E-cadherin to distinguish between ductal and lobular neoplasia, high molecular weight cytokeratins to differentiate usual ductal hyperplasia from ductal carcinoma in situ, immunohistochemical profiles to characterize site of origin of metastatic carcinomas, and cytokeratin stains to detect metastases in sentinel lymph nodes. Recent advances, practical considerations, and potential pitfalls in the use of immunohistochemistry in these five diagnostic categories are discussed herein.

引用

收藏

页码：1076 / 1091

页数：16

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