Complex-trait genetics: emergence of multivariate strategies

被引：41

作者：

Phillips, TJ ^{[1
]}

Belknap, JK

机构：

[1] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Portland Alcohol Res Ctr, Portland, OR 97201 USA

[3] Vet Affairs Med Ctr, Res Serv, Portland, OR 97201 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 06期

关键词：

D O I：

10.1038/nrn847

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Complex traits, including many disease-related traits, are influenced by multiple genes. Bivariate approaches that associate one gene with one trait are yielding to multivariate methods to synthesize the effects of multiple genes, integrate results across independent studies, and aid in the identification of coordinated pathways and interactions between loci.

引用

页码：478 / 485

页数：9

共 69 条

[1] Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats [J].

Aitman, TJ ;

Glazier, AM ;

Wallace, CA ;

Cooper, LD ;

Norsworthy, PJ ;

Wahid, FN ;

Al-Majali, KM ;

Trembling, PM ;

Mann, CJ ;

Shoulders, CC ;

Graf, D ;

St Lezin, E ;

Kurtz, TW ;

Kren, V ;

Pravenec, M ;

Ibrahimi, A ;

Abumrad, NA ;

Stanton, LW ;

Scott, J .

NATURE GENETICS, 1999, 21 (01) :76-83

[2]

Aldenderfer M., 1984, Cluster Analysis, DOI DOI 10.4135/9781412983648

[3]

Allison DB, 1998, GENETICS, V148, P859

[4]

[Anonymous], 1994, HDB RES SYNTHESIS

[5]

[Anonymous], 2000, META ANAL MED HLTH P, DOI DOI 10.1201/9780203909935

[6] Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior [J].

Bale, TL ;

Picetti, R ;

Contarino, A ;

Koob, GF ;

Vale, WW ;

Lee, KF .

JOURNAL OF NEUROSCIENCE, 2002, 22 (01) :193-199

[7]

Basten C., 2001, QTL Cartographer

[8]

Bayes M., 1763, PHILOS T ROY SOC LON, V53, P370, DOI DOI 10.1098/RSTL.1763.0053

[9]

BECKER BJ, 1994, HDB RES SYNTHESIS, P216

[10] QUANTITATIVE-TRAIT-LOCI (QTL) APPLICATIONS TO SUBSTANCES OF ABUSE - PHYSICAL-DEPENDENCE STUDIES WITH NITROUS-OXIDE AND ETHANOL IN BXD MICE [J].

BELKNAP, JK ;

METTEN, P ;

HELMS, ML ;

OTOOLE, LA ;

ANGELIGADE, S ;

CRABBE, JC ;

PHILLIPS, TJ .

BEHAVIOR GENETICS, 1993, 23 (02) :213-222

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