Complex-trait genetics: emergence of multivariate strategies

被引：41

作者：

Phillips, TJ ^{[1
]}

Belknap, JK

机构：

[1] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Portland Alcohol Res Ctr, Portland, OR 97201 USA

[3] Vet Affairs Med Ctr, Res Serv, Portland, OR 97201 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 06期

关键词：

D O I：

10.1038/nrn847

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Complex traits, including many disease-related traits, are influenced by multiple genes. Bivariate approaches that associate one gene with one trait are yielding to multivariate methods to synthesize the effects of multiple genes, integrate results across independent studies, and aid in the identification of coordinated pathways and interactions between loci.

引用

页码：478 / 485

页数：9

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