Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that "Slip" through the Human Mucus Barrier

被引：493

作者：

Wang, Ying-Ying ^{[1
]}

Lai, Samuel K. ^{[2
]}

Suk, Jung Soo ^{[1
]}

Pace, Amanda ^{[2
]}

Cone, Richard ^{[4
,5
]}

Hanes, Justin ^{[1
,2
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Oncol, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA

[5] Johns Hopkins Univ, Dept Biophys, Baltimore, MD 21218 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 50期

关键词：

drug delivery; mucosal tissues; nanomedicine; particle tracking; surface chemistry;

D O I：

10.1002/anie.200803526

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9726 / 9729

页数：4

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