Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

被引：129

作者：

Gao, Jian-Wei ^{[1
]}

Rizzo, Stefania ^{[2
]}

Ma, Li-Hong ^{[1
]}

Qiu, Xiang-Yu ^{[3
]}

Warth, Arne ^{[3
,4
]}

Seki, Nobuhiko ^{[5
]}

Hasegawa, Mizue ^{[6
,7
]}

Zou, Jia-Wei ^{[1
]}

Li, Qian ^{[1
]}

Femia, Marco ^{[8
]}

Lv, Tang-Feng ^{[1
]}

Song, Yong ^{[1
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Sch Med, Dept Resp Med, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China

[2] European Inst Oncol, Dept Radiol, Milan, Italy

[3] Nanjing Univ, Jinling Hosp, Sch Med, Res Inst Gen Surg, Nanjing 210002, Jiangsu, Peoples R China

[4] German Ctr Lung Res DZL, Translat Lung Res Ctr Heidelberg TLRC, Heidelberg, Germany

[5] Teikyo Univ, Sch Med, Dept Internal Med, Div Med Oncol,Itabashi Ku, Tokyo, Japan

[6] Saitama Med Univ, Saitama Int Med Ctr, Dept Diagnost Radiol, Saitama, Japan

[7] Tokyo Womens Med Univ, Yachiyo Med Ctr, Dept Resp Med, Tokyo, Japan

[8] Univ Milan, Postgrad Sch Radiodiagnost, Milan, Italy

来源：

TRANSLATIONAL LUNG CANCER RESEARCH | 2017年 / 6卷 / 01期

关键词：

Ground-glass opacity (GGO); computed tomography (CT); pathology; driver genes; epidermal growth factor receptor gene (EGFR); anaplastic lymphoma kinase gene (ALK); Kirsten rat sarcoma viral oncogene homolog (KRAS); GROWTH-FACTOR-RECEPTOR; CELL LUNG-CANCER; THIN-SECTION CT; INTERNATIONAL MULTIDISCIPLINARY CLASSIFICATION; RESPIRATORY SOCIETY CLASSIFICATION; ATYPICAL ADENOMATOUS HYPERPLASIA; KRAS GENE-MUTATIONS; HIGH-RESOLUTION CT; BRONCHIOLOALVEOLAR CARCINOMA; FDG-PET;

D O I：

10.21037/tlcr.2017.01.02

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their preinvasive lesions. Evaluation of pulmonary GGO and investigation of the correlation between CT imaging features and lung adenocarcinoma subtypes or driver genes can be helpful in confirming the diagnosis and in guiding the clinical management. Our review focuses on the pathologic characteristics of GGO detected at CT, involving histopathology and molecular pathology.

引用

页码：68 / 75

页数：8

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