Structure-based design of non-peptide HIV protease inhibitors

被引:30
作者
Ghosh, AK
Shin, D
Swanson, L
Krishnan, K
Cho, H
Hussain, KA
Walters, DE
Holland, L
Buthod, J
机构
[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA
[2] Finch Univ Hlth Sci Chicago Med Sch, Dept Biol Chem, N Chicago, IL 60064 USA
[3] IT Res Inst, Dept Life Sci, Chicago, IL 60616 USA
来源
FARMACO | 2001年 / 56卷 / 1-2期
关键词
protease; inhibitor; ligand; design; non-peptide;
D O I
10.1016/S0014-827X(01)01025-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A. number of structurally novel P-2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors. (C) 2001 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:29 / 32
页数:4
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